The splice of two links is an operation defined by Eisenbund and Neumann that generalizes several other operations on links, such as the connected sum, the cabling or the disjoint union. There has been much interest to understand the behavior of different link invariants under the splice operation (genus, fiberability, Conway polynomial, Heegaard-Floer homology among others) and the goal of this talk is to present a formula relating the colored signature of the splice of two oriented links to the colored signatures of its two constituent links. As an immediate consequence, we have that the conventional univariate Levine-Tristram signature of a splice depends, in general, on the colored (or multivariate) signatures of the summands. If time permits we will discuss the intricacies of the non generic case. This is a joint work with Alex Degtyarev and Vincent Florens.